We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.
To save content items to your account,
please confirm that you agree to abide by our usage policies.
If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account.
Find out more about saving content to .
To save content items to your Kindle, first ensure coreplatform@cambridge.org
is added to your Approved Personal Document E-mail List under your Personal Document Settings
on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part
of your Kindle email address below.
Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations.
‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi.
‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
In spite of numerous advances that have been made in the screening and management of patients with breast cancer, an unacceptable number of patients die of this disease even though they may have had optimal therapy and management. It is therefore necessary to assess the possible impact of different treatment modalities currently used more in other tumour types and consider this application to the treatment of breast cancer. These include immunotherapy (active: vaccines, and passive: antibodies), gene therapy, antisense technology and antiangiogenic agents.
Cancer and the immune system
Macfarlane Burnet (1970) postulated that the immune system kept potential cancer cells under surveillance and could detect and kill thousands of emerging cancer cells every day. This concept had gradually fallen out of favour as regards the common solid tumours as they do not appear to be increased in conditions where the immune system is compromised, such as autoimmune deficiency syndrome (AIDS) and renal transplant patients. However, both of these conditions have an increased incidence of viral driven cancers such as Epstein–Barr Virus (EBV) associated lymphomas and HHV-8-associated Kaposi's sarcoma. In these conditions there is a foreign viral antigen(s) which can be detected and contained by a healthy immune system and the failure to do so leads to viraldriven proliferation and oncogenesis. The absence of increased breast, lung and bowel cancer in HIV infection however, does not mean that the immune system has no role in containment of tumour progression.
Recommend this
Email your librarian or administrator to recommend adding this to your organisation's collection.